Symbol
Name
ID

Themis
thymocyte selection associated
MGI:2443552

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased T cell proliferation

increased T cell proliferation

abnormal thymus medulla morphology

small thymus medulla

decreased thymocyte number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal negative T cell selection

abnormal positive T cell selection

increased double-positive T cell number

decreased B-1a cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta memory T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased NK T cell number

decreased alpha-beta T cell number

increased memory T cell number

decreased regulatory T cell number

decreased T cell number

decreased single-positive T cell number

abnormal lymphocyte morphology

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology

abnormal memory T cell morphology

abnormal regulatory T cell morphology

decreased splenocyte number

impaired humoral immune response

Availability

Mouse Genotype

Themis^5AT161/Themis^5AT161

Themis^m1Btlr/Themis^m1Btlr

Themis^m2Btlr/Themis^m2Btlr

Themis^m3Btlr/Themis^m3Btlr

Themis^M4Btlr/Themis^M4Btlr

Themis^m5Btlr/Themis^m5Btlr

Themis^Spotr/Themis^Spotr

Themis^tm1.1Hko/Themis^tm1.1Hko

Themis^tm1Gasc/Themis^tm1Gasc

Themis^tm1Hasu/Themis^tm1Hasu

Themis^tm1Lov/Themis^tm1Lov

Themis^Spotr/Themis⁺

Themis^tm1.1Hko/Themis⁺

Themis^tm1Hasu/Themis⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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